Chun-houh Chen 
Research Fellow, Institute of Statistical Science, Academia Sinica
陳 君 厚 研 究 員
Education

Ph.D.     (1992)  University of California, Los Angeles  (1987 - 92)

                              Major: Mathematics (Program in Statistics)　

M.S.      (1990)   University of California, Los Angeles  (1987 - 90)

                              Major: Mathematics (Program in Statistics)　

B.S.      (1984)   National Chung-Hsing University      (1980 - 84)

                              Major: Statistics

PROFESSIONAL EXPERIENCE

2011/1-present Research Fellow, 
Institute of Statistical Science, Academia Sinica,
Taipei, Taiwan, R.O.C.

2002/2-2011/1 Associate Research Fellow, 
Institute of Statistical Science, Academia Sinica,
Taipei, Taiwan, R.O.C.

1993/8-2002/2 Assistant Research Fellow, 
Institute of Statistical Science, Academia Sinica,
Taipei, Taiwan, R.O.C.

1992/9-1993/8 Assistant Professor,
Department of Statistics/Computer and Information Systems,
George Washington University,
Washington, D.C., U.S.A.

Part Time:

2007/8--present Adjunct Associate Professor,
Institute of Statistics
National Central University, Jhongli, Taiwan, R.O.C.

1998/8-1999/7 Adjunct Assistant Professor,
Graduate Institute of Epidemiology, College of Public Health, 
National Taiwan University, Taipei, Taiwan, R.O.C.

1994/1-1995/6 Adjunct Associate Professor,
Institute of Mathematical Statistics, National Chung-Cheng University
Chia-Yi, Taiwan, R.O.C.

　

EDITORIAL AND OTHER ACADEMIC SERVICES

Editorships:
Current:

Associate Editor, BMC (BioMed Central) Research Notes, 2008~
Associate Editor, Computational Statistics, 2004~
Associate Editor, Computational Statistics and Data Analysis, 2004~
Statistics Consultant, Taiwanese Journal of Psychiatry, 1996~

Past:

Associate Editor, Statistica Sinica, 2005~2008
Associate Editor, Journal of the Korean Statistical Society, 2002~2005


Academic Society:

BoD (Board of Directors) Member for the Asian Regional Section (ARS) of the International Association for Statistical Computing (IASC) (2004-present)

Conference Organizer:

  1. Chairman, Statistical Computation and Visualization 2008 (SCV2008), Taipei, Taiwan, December 1-3, 2008.

  2. Member, Program Committee, The 3rd IEEE Pacific Visualization Symposium (PacificVis 2010), Taipei, Taiwan, March 2-5, 2010.

  3. Member, Scientific Program Committee, Joint meeting of 4th World Conference of International Association for Statistical Computing (IASC) and 6th Conference of Asian Regional Section of IASC, Yokohama, Japan, December 5-8, 2008.

  4. Member, International Organizing Committee, The 2007 IASC-ARS Special Conference, Seoul, June 7-8, 2007.

  5. Member, Scientific Program Committee, Workshop on Data and Information
    Visualization, Berlin, August 2006.

  6. Member, Scientific Program Committee, The 4th Conference of the Asian Regional Section (ARS) of the International Association for the Statistical Computing (IASC), Busan, December 2002.
     

RESEARCH INTERESTS

Bioinformatics; Data/Information Visualization; Dimension Reduction; Matrix Visualization; Multivariate Statistical Methods; Pattern Recognition.

MAJOR AWARDS AND HONORS

Presented the Opening Keynote Lecture at the 16th Symposium of International Association for Statistical Computing (COMPSTAT 2004) at Prague, Czech Republic (August 23-27, 2004) with the title “Matrix Visualization and Information Mining.”

PUBLICATIONS(* for corresponding author)
Journals:

  1. Hou, C. C., Chen, C. H., Yang, N. S., Chen, Y. P., Lo, C. P., Wang, S. Y., Tien, Y. J., Tsai, P. W., and Shyur, L. F., (2010), "Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants." to appear in Journal of Nutritional Biochemistry.

  2. Wu, H. M., Tien, Y. J., and Chen, C. H*., (2010), "GAP: A graphical environment for matrix visualization and cluster analysis." Computational Statistics and Data Analysis, 54 (3), 767-778 (October 8, 2008).

  3. Lin, S. H., Liu, C. M., Liu, Y. L., Fann, C. S. J., Hsiao, P. C., Wu, J. Y., Hung, S. I., Chen, C. H., Wu, H. M., Jou, Y. S., Liu, S. K., Hunag, T. J., Hsieh, M. H., Chang, C. C., Yang, W. C., Lin, J. J., Chou, F. H. C., Faraone, S. V., Tsuang, M. T., Hwu, H. G., and Chen, W. J., (2009), "Clustering by neurocognition for fine-mapping of the schizophrenia susceptibility loci on chromosome 6p." Genes, Brain and Behavior, 8(8), 785-294, July 21, 2009.

  4. Chien, S. C., Young, P. H., Hsu, Y. J., Chen, C. H., Tien, Y. J., Shiu, S. Y., Li, T. H., Yang, C. W., Marimuthu, P., Tsai, L. F. L., Yang, W. C., (2009), "Anti-diabetic properties of three common Bidens pilosa variants in Taiwan." Phytochemistry, 70 (10), 1246-1254, July 11, 2009.

  5. Lee, Y. S., Chen, C. H., Tsai, C. N., Chao, A., and Wang, T. H., (2009), "Microarray Labeling Extension Values: Laboratory Signatures for Affymetrix GeneChips." Nucleic Acids Research, (18 March 2009).

  6. Wang, C. Y., Staniforth, V., Chiao, M. T., Hou, C. C., Wu, H. M., Yeh, K. C., Chen, C. H., Hwang, P. I., Wen, T. N., Shyur, L. F., and Yang, N. S., (2008), "Genomics and proteomics of immune modulatory effects of a butanol fraction of Echinacea purpurea in human dendritic cells." BMC Genomics, 9:479 (13 October 2008).

  7. Wu, T. T., Sun, W., Yuan, S. S., Chen, C. H., W., Li, K. C., (2008), "A Method for Analyzing Censored Survival Phenotype with Gene Expression Data." BMC Bioinformatics, 9:417 (6 October 2008).

  8. Lee, Y. S., Chao, A., Chao, A. S., Chang, S. D., Chen, C. H., Wu, W. M., Wang, T. H., Wang, H. S., (2008), "CGcgh: a tool for molecular karyotyping using DNA microarray-based comparative genomic hybridization (array-CGH)," Journal of Biomedical Science, 15 (6):687-96. (available online 19 August 2008).

  9. Liu, Y. L., Fann, C. S. J., Liu, C. M., Chen, W. J., Wu, J. Y., Hung, S. I., Chen, C. H., Jou, Y. S., Liu, S. K., Hwang, T. J., Hsieh, M. H., Chang, C. C., Yang, W. C., Lin, J. J., Chou, F. H. C., Faraone, S. V., Tsuang, M. T., and,Hwu, H. G., (2008), "RASD2, MYH9, and CACNG2 Genes at Chromosome 22q12 Associated with the Subgroup of Schizophrenia with Non-deficit in Sustained Attention and Executive Function." Biological Psychiatry, 64 (9), 789-796 (20 June 2008).

  10. Ho, M. R., Jang, W. J., Chen, C. H., Ch'ang, L. Y., and Lin, W. C., (2008), "Designating Eukaryotic Orthology via Transcription Units." Nucleic Acids Research, 36 (10), 3436-3442.

  11. Yeh, L. L., Hwu, H. G., Chen, C. H., Chen, C. H., Wu, A. C. C., (2008), "Factors Related to Perceived Needs of Primary Caregivers of Patients with Schizophrenia." Journal of the Formosan Medical Association. 107 (8), 644-652.

  12. Tien, Y. J., Lee, Y. S., Wu, H. M., and Chen, C. H*., (2008), "Methods for Simultaneously Identifying Coherent Local Clusters with Smooth Global Patterns in Gene Expression Profiles." BMC Bioinformatics. 9:155, (20 March 2008).

  13. Chou, C. C., Hsiao, H. Y., Hong, Q. S., Chen, C. H., Peng, Y. W., Chen, H. W., and Yang, P. C., (2008) "Single-Walled Carbon Nanotubes can Induce Pulmonary Injury in Mouse Model." Nano Letters, 8 (2), 437-445, 2008.

  14. Chen, J. J., Tsai, C. A., Tzeng, S., and Chen, C. H*., (2007), "Gene Selection with Multiple Ordering Criteria." BMC Bioinformatics 2007, 8:74.

  15. Chen, H. Y., Yu, S. L., Chen, C. H., Chang, G. C., Chen, C. Y., Yuan, A., Cheng, C. L., Wang, C. H., Terng, H. J., Kao, S. F., Chen, W. J., Chen, J. J. W., Yang, P. C., (2007), " A Five-Gene Signature and Clinical Outcome in Non-Small-Cell Lung Cancer." The New England Journal of Medicine, 356:11-20, January 4, 2007.

  16. Sher, Y. P., Chou, C. C., Chou , R. H., Wu, H. M., Chang, W. W-S, Chen, C. H., Wu, C. W., Yang, P. C., Yu, C. L., and Peck, K., (2006) " Human Kallikrein 8 Protease Confers a Favorable Clinical Outcome in Non-Small Cell Lung Cancer by Suppressing Tumor Cell Invasiveness." Cancer Research, 66, 11763-11770, December 15, 2006.

  17. Pan, W. H., Chang, Y. P., Yeh, N. H., Chen, C. H., and Tzeng, S. L., (2006), "Evaluating the DOH (Department of Health) Food Guide Based on Taiwanese Food Choices." Nutritional Sciences Journal, 30 (3), 116-126.

  18. Chiu, M. J., Hua, M. S., Chen, T. F., Hwu, H. G., Kao, C. H., and Chen, C. H., (2006), "Brain responses of explicit and implicit memory - an ERP study." NeuroReport, 17 (14), 1483~1486 (2 October 2006).

  19. Chen, J. J., Tsai, C. A., Moon, H., Ahn, H., and Chen, C. H., (2006) "Decision threshold adjustment in class prediction." SAR and QSAR in Environmental Research, 17 (3), 337-352 (June 2006).

  20. Chou, C. C., Lee, T. T., Chen, C. H., Hsiao, H. Y., Lin, Y. L., Ho, M. S., Yang, P. C., and Peck, K., (2006) "Design of microarray probes for virus identification and detection of emerging viruses at the genus level." BMC Bioinformatics, 2006, 7:232 (28 Apr 2006).

  21. Liu, Y. L., Fann, C. S. J., Liu, C. M., Chen, W. J., Wu, J. Y., Hung, S. I., Chen, C. H., Jou, Y. S., Liu, S. K., Hwang, T. J., Shieh, M. H., Ouyang, W. C., Chan, H. Y., Chen, J. J., Lin, C. Y., Lee, S. F. C., Hwu, H. G., (2006), "A Single Nucleotide Polymorphism Fine Mapping Study of Chromosome 1q42.1 Reveals the Vulnerability Genes for Schizophrenia, GNPAT and DISC1: Association with Impairment of Sustained Attention." Biological Psychiatry, 60, 554-562.

  22. Pan, W. H., Lynn, K. S., Chen, C. H., Wu, Y. L., Lin, C. Y., and Chang, H. Y., (2006), "Using endophenotypes for pathway clusters to map complex disease genes." Genetic Epidemiology, 30 (2):143-54 (2006 Feb).

  23. Lee, Y. S., Chen, C. H., Chao, A., Chen, E. S., Wei, M. L., Chen, L. K., Yang, K., Lin, M. C., Wang, Y. H., Liu, J. W., Eng, H. L., Chiang, P. C., Wu, T. S., Tsao, K. C., Huang, C. G., Tien, Y. J., Wang, T. H., Wang, H. S., Lee, Y. S., (2005), "Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)." BMC Genomics, 6:132 (21 Sep 2005).

  24. Chen, J. J. W., Lin, Y. C., Yao, P. L., Yuan, A., Chen, H. Y., Shun, C. T., Tsai, M. F., Chen, C. H., and Yang, P. C., (2005), "Tumor-Associated Macrophages: The Double Edged Sword in Cancer Progression." Journal of Clinical Oncology 23, 1-12.

  25. Tsai, C. A., Lee, T. C., Ho, I. C., Yang, U. C., Chen, C. H., and Chen, J. J., (2005), "Multi-class Clustering and Prediction in the Analysis of Microarray Data." Mathematical Biosciences 193 (1):79-100.

  26. Tsai, C. A., Chen, C. H., Lee, T. C., Ho, I. C., Yang, U. C., and Chen, J. J., (2004), "Gene selection for sample classifications in microarray experiments." DNA and Cell Biology 23, 607-614.

  27. Chou, C. C., Chen, C. H., Lee, T. T., and Peck, K., (2004), "Optimization of probe length and the number of probes per gene for optimal microarray analysis of gene expression." Nucleic Acids Research 32 (12).

  28. Hwu, H. G., Chen, C. H., Hwang, T. J., Liu, C. M., Cheng, J. J., Lin, S. K., Liu, S. K., Chen, C. H., Chi, Y. Y., OuYoung, C. W., Lin, H. N., and Chen, W. J., (2002). Symptom Patterns and Subgrouping of Schizophrenic Patients: Significance of Negative Symptoms Assessed on Admission. Schizophrenia Research 56, 105-119 (1 July 2002).

  29. Chen, C. H*. (2002), Generalized Association Plots for Information Visualization: The applications of the convergence of iteratively formed correlation matrices." Statistica Sinica 12, 1-23.

  30. Chen, C. H., and Li, K. C. (2001), "Generalization of Fisher's Linear Discriminant Analysis via the Approach of Sliced Inverse Regression," Journal of the Korean Statistical Society 30, 193-217.

  31. Chen, C. H*., and Chen, J. A. (2000), "Interactive Diagnostic Plots for Multidimensional Scaling with Applications in Psychosis Disorder Data Analysis." Statistica Sinica 10, 665-691.

  32. Li, K. C., Lue, H. H., and Chen, C. H. (2000), "Interactive Tree-Structured Regression via Principal Hessian Directions." Journal of the American Statistical Association 95, 547-560.

  33. Li, K. C., Wang, J. L., and Chen, C. H. (1999), "Dimension Reduction for Censored Regression Data." Annals of Statistics 27, 1-23.

  34. Chen, C. H., and Li, K. C. (1998), "Can SIR be as Popular as Multiple Linear Regression?" Statistica Sinica 8, 289-316.

  35. Lin A. S., Chen, C. H., Hwu H. G., Lin H. N., and Chen J. A. (1998), "Psychopathological Dimensions in Schizophrenia: A Correlational Approach to Items of the SANS and SAPS." Psychiatry Research 77, 121-130.

    36. Book Chapters: 

  36. Chen, J. J. and Chen, C. H., (2010). "Microarray Gene Expression." Encyclopedia of Biopharmaceutical Statistics, 3rd Edition (S. Chow ed.), Marcel Dekker, Inc., New York, ???-???, 2009.

  37. Wu, H. M., Tzeng, S. L., and Chen, C. H*., (2008), "Matrix Visualization." in Handbook of Computational Statistics: Data Visualization, Chen CH, Härdle W, Unwin A (eds). Berlin: Springer-Verlag, 681-708, 2008.

  38. Unwin, A., Chen, C. H., and Härdle, W., (2008), "Introduction." Handbook of Computational Statistics: Data Visualization, Chen CH, Härdle W, Unwin A (eds). Berlin: Springer-Verlag, 3-12, 2008.

  39. Chen, C. H., (2005), "Sliced Inverse Regression," Encyclopedia of Statistics in Behavioral Sciences, Eds. B. Everitt and D. C. Howell, Wiley, 4, 1856-1863.

  40. Chen, C. H., and Li, K. C., (2004), "A Three-way Classification Strategy for Reducing Class-Abundance: the Zip Code Recognition Example," Optimality, J. Rojo & V. Perez-Abreu, Editors. I.M.S. Lecture Notes-Monograph Series 44, 63-86.

  41. Chen, J. J. and Chen, C. H., (2003). "Microarray Gene Expression." Encyclopedia of Biopharmaceutical Statistics, 2nd Edition (S. Chow ed.), Marcel Dekker, Inc., New York, 599-613, 2003.

    42. Refereed Proceedings: 

  42. Tzeng, S. L., Wu, H. M., and Chen, C. H*., (2009), "Selection of Proximity Measures for Matrix Visualization of Binary Data." Proceedings of the 2009 2nd International Conference on BioMedical Engineering and Informatics (BMEI 2009), 1932-1940, Tianjin, China (available in IEEE Xplore Digital Library).

  43. Chen, C. H., Hwu, H. G., Jang, W. J., Kao, C. H., Tien, Y. J., Tzeng, S., and Wu, H. M. (2004). “Matrix Visualization and Information Mining,” Proceedings in Computational Statistics 2004 (Compstat 2004), 85-100, Physika Verlag, Heidelberg.

  44. Chang, S. C., Chen, C. H., Chi, Y. Y., and Ouyoung, C. W. (2002). “Relativity and Resolution for High Dimensional Information Visualization with Generalized Association Plots (GAP).” Section for Invited Papers, Proceedings in Computational Statistics 2002 (Compstat 2002), Berlin, Germany, 55-66.

    Proceedings: 

  45. Chen, C. H. (1999), “Extensions of Generalized Association Plots.” 1999 Proceedings of the Section on Statistical Graphics of the American Statistical Association, 111-116.

  46. Chen, C. H. (1996), “The Properties and Applications of the Convergence of Correlation Matrices.” 1996 Proceedings of the Section on Statistical Graphics of the American Statistical Association, 49-54.

    47. Books: 

  47. Handbook of Computational Statistics: Data Visualization. Chen CH, Härdle W, Unwin A (eds). Berlin: Springer-Verlag, 2008.

　

SELECTED INVITED PRESENTATIONS:

Invited Workshops:

  1. "Information Visualization for High Dimensional Biomedical Data: the Matrix Visualization Approach." International Conference of Bioinformatics (InCoB) 2008, October 20-23, 2008, Taipei, Taiwan.

  2. “High dimensional data visualization: the matrix visualization approach.” International Conference on the Frontiers of Statistics: High Dimensional Data Analysis, 11-14 August, 2007, Kunming, China.
     

  3. Tutorial on “Matrix Visualization and Information Mining,” The Fourth Asia Pacific Bioinformatics Conference, 13-16 Feb, 2006, Taipei, Taiwan.
     

  4. “GAP: Generalized Association Plots for Dimension Free Data Visualization.” The 5th IASC Asian Conference on Statistical Computing (IascAsian05), 15-17 December 2005, Hong Kong.
     

  5. Two-day Workshop on “Dimension Free Data Visualization and Information Mining,” Institute of Statistical Mathematics, Tokyo, Japan, 5-6 November, 2004
     

  6. “Data- and Informationvisualization: Generalized Association Plots,” Institute for Statistics und Econometrics, Humboldt-Universität zu Berlin, Germany, August 18, 2004.

    Invited Talks:

  7. "Visual information mining of high-dimensional data structure with generalized association plots." Keynote Lecture, Symposium on Large-scale Data Linkage, Data Mining and Statistical Methods, December 11-12, 2008, Tokyo, Japan.

  8. “Matrix Visualization for High-Dimensional Categorical Data Structure with a Cartography Link.” 2008 Joint Statistical Meetings, July 29 - August 2, 2007, Salt Lake City, USA.
     

  9. “Applications of Matrix Visualization for Information Mining.” Royal Statistical Society Annual Conference 2006, 11th to 14th September, 2006, Belfast.
     

  10. “Applications of Matrix Visualization for Information Mining.” Korean Statistical Society 2006 Spring Conference, May 26-27, 2006, Daegu, Korea.
     

  11. “Visualization and Information Mining for High Dimensional Biomedical Data.” NCTR Seminar, July 29, 2005, National Center for Toxicological Research, FDA, Jefferson, Arkansas, USA.
     

  12. “Dimension Free Data Visualization and Information Mining.” Keynote Lecture, 16th Symposium of International Association for Statistical Computing (COMPSTAT 2004), August 23-27, 2004, Prague, Czech Republic.
     

  13. “Information Visualization and Clustering for High Dimensional Categorical Biomedical Data Structure.” Visiting Professor Lecture Series, FDA Center for Drug Evaluation and Research (CDER), October 4, 2002, Rockville, MD.
     

  14. “Relativity and Resolution for High Dimensional Information Visualization with Generalized Association Plots (GAP).” 15th Symposium of International Association for Statistical Computing (COMPSTAT 2002), August 24-28, 2002, Berlin, Germany.
     

  15. “Information Visualization with Generalized Association Plots (GAP).” Statistica Sinica Invited Paper, 2001 Joint Statistical Meetings, August 6, 2001, Atlanta, Georgia, USA.
     

  16. “A Three-Way Subclassification Approach to Multiple-Class Discriminant Analysis.” 1998 Joint Statistical Meetings, August 11, Dallas, TX, U.S.A.
     

  17. “Identification of Subject-Clusters and Variable-Groups in a Longitudinal Data Profile via Data Visualization.” 1997 IMS Asian and Pacific Regional Meeting Joint with CIPS and CSA, July 9, Taipei, Taiwan, R.O.C.
     

  18. “Discriminant Analysis, Tree-Structured Classification, and Sliced Inverse Regression.” 1994 IMS Annual Meeting, June 22, Chapel Hill, NC, U.S.A.


　
Mailing Address 

Institute of Statistical Science
Academia Sinica
128 Academia Rd. Sec.2, Nankang, Taipei, Taiwan 11529
Tel: 886-2-27835611 ext: 407